PE-22-28 Peptide 8mg Lyophilized Powder for Research

PE-22-28 (8mg)

€48.60

Categories: Core Peptides, Healing and Regeneration research, Sleep Enhancement Research Tags: Depression, In-vitro, Neuropharmacology, PE-22-28, Peptide, Research, Scientific Study, Spadin Derivative, TREK-1 Brand: Core Peptides

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Ultimate PE-22-28 Peptide: Proven 8mg for Depression Research

⚠️ Research Use Only. This product is intended exclusively for in-vitro scientific research. It is not approved for human or animal consumption, clinical use, or therapeutic application.

1.Introduction to PE-22-28 Peptide

2.Product Details

3.Understanding PE-22-28: A Synthetic Spadin Derivative

4.Mechanism of Action and Research Applications

5.About the Brand

6.Frequently Asked Questions (FAQ)

1. Introduction to PE-22-28 Peptide

PE-22-28 peptide, a synthetic derivative of the naturally occurring protein spadin, is a subject of intense interest in depression research. This 8mg formulation provides a high-purity compound for in-vitro studies, allowing researchers to investigate its unique interaction with the TREK-1 receptor. Recognized as potentially the shortest and most efficient sequence capable of blocking the TREK-1 channel, PE-22-28 offers a promising avenue for understanding and potentially modulating mood-related neurological pathways. Its enhanced potency compared to spadin makes it a valuable tool for advanced neuropharmacological investigations.

2. Product Details

Attribute	Detail
Brand	[Brand Name – placeholder]
Size	8mg
Type	PE-22-28 Peptide
Form	Lyophilized powder
Purity	>99%
SKU	P-PE2228-8

3. Understanding PE-22-28: A Synthetic Spadin Derivative

PE-22-28 is a synthetic derivative of the naturally occurring protein called spadin. Spadin is a natural peptide derived from sortilin, an abundant protein in the central nervous system. PE-22-28 peptide is one such shortened peptide derivative of this protein; similar to spadin, PE-22-28 research indicates it primarily acts via the TREK-1 receptor. Researchers Djillani et al. commented that PE-22–28 may be “the shortest, most efficient sequence capable of blocking the TREK-1 channel” and may have a potentially higher potency in research settings than spadin.

TREK-1 (TWIK-related potassium channel) receptor is a two-pore potassium channel recently identified as a potential target for studying and modifying animal models of depression. In 2010, research suggested that when TREK-1 receptors were removed from murine models, they became more resistant to depression. TREK-1 receptor is primarily found in the brain region, including the prefrontal cortex and hippocampus, i.e., areas governing mood, memory, and learning. Simulating the TREK-1 receptor may reduce neuron excitability, whereas reducing the receptor activity may increase neuron excitability. While mainly evaluated in the study of depression models, this receptor may also play a strong role in anesthesia, pain perception, and protection of neurons. This detailed understanding of PE-22-28’s origin and target receptor highlights its significance in neuroscientific research.

4. Mechanism of Action and Research Applications

The mechanism of action for PE-22-28 peptide is primarily mediated through its potent and selective antagonism of the TREK-1 potassium channel. By blocking TREK-1, PE-22-28 is hypothesized to increase neuronal excitability, a mechanism that has shown promise in preclinical models of depression. The TREK-1 channel is widely distributed in brain regions associated with mood regulation, such as the prefrontal cortex and hippocampus, making it a strategic target for antidepressant research. This specific interaction suggests a potential to modulate neural circuits involved in emotional processing and stress responses.

In research, PE-22-28 is investigated for its potential as a novel antidepressant agent, offering an alternative approach to existing pharmacological treatments. Its ability to influence neuronal activity through a distinct mechanism provides valuable insights into the pathophysiology of mood disorders. Furthermore, the broader implications of TREK-1 channel modulation extend to studies on anesthesia and pain perception, positioning PE-22-28 peptide as a versatile tool for exploring various neurological phenomena. Ongoing studies aim to further characterize its precise effects and evaluate its efficacy in diverse research models.

5. About the Brand

[1] is dedicated to providing high-quality research compounds for scientific exploration. With a commitment to purity and rigorous testing, we ensure that our products meet the exacting standards required for advanced laboratory studies. Our mission is to support the scientific community with reliable and well-characterized peptides, facilitating groundbreaking discoveries and advancements in various fields of research.

6. Frequently Asked Questions (FAQ)

Q1: What is PE-22-28 peptide?

PE-22-28 peptide is a synthetic derivative of spadin, primarily studied for its potent and selective antagonism of the TREK-1 potassium channel, making it a subject of interest in depression research.

Q2: How does PE-22-28 interact with the TREK-1 receptor?

PE-22-28 is believed to act as a potent blocker of the TREK-1 potassium channel, which is hypothesized to increase neuronal excitability and contribute to its potential antidepressant effects in research models.

Q3: Is PE-22-28 suitable for human use?

No, PE-22-28 is strictly for research use only. It is not approved for human or animal consumption, clinical use, or therapeutic application, and should only be handled by qualified professionals in a laboratory setting.

Q4: What are the research applications of PE-22-28 peptide?

PE-22-28 peptide is primarily studied in research for its potential in models of depression, as well as for its implications in understanding anesthesia and pain perception, making it a subject of interest in neuropharmacology.

Q5: Where can I buy PE-22-28 peptide for research?

PE-22-28 peptide for sale is available from specialized suppliers of research chemicals. Ensure that any supplier adheres to strict quality control and provides comprehensive product information for scientific use.

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PE-22-28 (8mg)

Ultimate PE-22-28 Peptide: Proven 8mg for Depression Research

Table of Contents

1. Introduction to PE-22-28 Peptide

2. Product Details

3. Understanding PE-22-28: A Synthetic Spadin Derivative

4. Mechanism of Action and Research Applications

5. About the Brand

6. Frequently Asked Questions (FAQ)

Reviews

Be the first to review “PE-22-28 (8mg)” Cancel reply

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PE-22-28 (8mg)

Ultimate PE-22-28 Peptide: Proven 8mg for Depression Research

Table of Contents

1. Introduction to PE-22-28 Peptide

2. Product Details

3. Understanding PE-22-28: A Synthetic Spadin Derivative

4. Mechanism of Action and Research Applications

5. About the Brand

6. Frequently Asked Questions (FAQ)

Reviews

Be the first to review “PE-22-28 (8mg)” Cancel reply

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